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This methylation profile is now acquired with the MBL stage3 and continues to be fairly steady over time. Nonetheless, some CLL have intratumor variability in selected regions, which may alter the expression of many genes and aid tumor evolution.seventy one Of Be aware, this variability is larger in U-CLL than in M-CLL which is associated with escalating amount of subclones.seven,seventy one

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Some diploma of immunophenotype overlap among the CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. In case the diagnosis is unsure determined by peripheral blood circulation cytometry, lymph node biopsy ought to be pursued.

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